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Your Position: Home > Integrin alpha 2b beta 3

Integrin alpha 2b beta 3

Brief Information

Name:Integrin alpha-IIb/beta-3
Target Synonym:Platelet Glycoprotein GPIIb-IIIa Complex
Number of Launched Drugs:5
Number of Drugs in Clinical Trials:7
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
IT3-H52W8 Human Human Integrin alpha 2b beta 3 (ITGAIIb&ITGB3) Heterodimer Protein, His Tag&Tag Free
IT3-H52W8-structure
IT3-H52W8-sds
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Part of Bioactivity data

IT3-H52W8-ELISA
Integrin alpha 2b beta 3 ELISA

Immobilized Human Fibronectin at 2 μg/mL (100 μL/well) can bind Human ITGAIIb&ITGB3 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT3-H52W8) with a linear range of 2-78 ng/mL (QC tested).

Protocol

Synonym Name

Integrin alpha 2b beta 3,ITGAIIb&ITGB3

Background

Integrin alpha IIb beta 3 exist in a conformational equilibrium clustered around four main states. These conformations range from a compact bent nodule to two partially extended intermediate conformers and finally to a fully upright state. Activation of blood platelets by physiological stimuli at sites of vascular injury induces inside-out signaling, resulting in a conformational change of the prototype Integrin alpha IIb beta 3 from an inactive to an active state competent to bind soluble fibrinogen. Furthermore, ligand occupancy of Integrin alpha IIb beta 3 outside-in signaling and additional conformational changes of the receptor, leading to the exposure of extracellular neoepitopes termed ligand-induced binding sites (LIBS), which are recognized by anti-LIBS monoclonal antibodies.

Clinical and Translational Updates

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